Matthew Vogt, MD, PhD

Matthew R. Vogt, MD, PhD is an Assistant Professor in Pediatrics (Division of Infectious Diseases) and Microbiology & Immunology at the University of North Carolina at Chapel Hill School of Medicine. Dr. Vogt obtained his degrees at the Washington University in St. Louis School of Medicine. His thesis work in the laboratory of Michael S. Diamond, MD, PhD focused on the study of antibody modification of West Nile virus infection. He completed a residency in Pediatrics at the Boston Combined Residency Program of Boston Children’s Hospital and Boston Medical Center. Dr. Vogt then moved to Vanderbilt University Medical Center for his fellowship in Pediatric Infectious Diseases. With the support of the Pediatric Infectious Diseases Society-St. Jude Children’s Research Hospital Fellowship Program in Basic Research he joined the laboratory of James E. Crowe, Jr., MD. In the Crowe laboratory, Dr. Vogt isolated human monoclonal antibodies from subjects infected with enterovirus D68, a virus that typically causes respiratory illness but also causes increasingly large outbreaks of acute flaccid myelitis, a polio-like paralyzing illness. In 2020 Dr. Vogt joined the faculty at UNC. He sees patients as a consultant on the Pediatric Infectious Diseases service at N.C. Children’s Hospital and runs a basic science laboratory. The Vogt laboratory is focused on understanding why common pediatric respiratory virus infections cause severe disease in some people. Currently they focus on enteroviruses, studying both the pathogen and the host immune response. Projects focus on use of reverse genetic systems to create reporter viruses to infect both human respiratory epithelial cultures and small animal models such as mice. Human antibody effects on pathogenesis are also of particular interest, as are isolating new monoclonal antibodies that cross-react between enteroviruses.